World War III

World War III was a global conflict on Earth, waged in part with atomic weapons, in which millions perished.

The initial nuclear exchanges were fired on May 1, 2053, as witnessed by the inhabitants of Vanguard L-5 colony. (TLE novel: The Sundered)

The Siege of Las Vegas was a significant battle in the war. (DS9 short story: "Second star to the right...")