Far star bug

The "Far-star" bug was a popular expression in the 23rd century for Humans who felt the inexplicable urge to venture off Earth to some distant Federation colony.

One use of the slang was in 2267, when Aaron Cole was describing his time on Versailles, and why he decided to live off on a distant moon rather than Earth. (TOS novel: "The Case of the Colonist's Corpse")