Ceti Alpha V colony

In an alternate timeline where the Xindi were successful in destroying Earth in 2154, the Ceti Alpha V colony was one of the last remaining Human settlements through the mid 2150s to mid 2160s.

Following the destruction of Earth and other major Human colonies, the Enterprise (NX-01) led a refugee convoy of Human ships to Ceti Alpha V where a colony of just less than 6,000 was established on the surface. Upon arriving at the planet, civilian ships were dismantled to construct the buildings that would make up the colony. By the mid 2160s, the colony was firmly established with many of the buildings being closely clustered around a small reservior. The colonies location was an intense secret, and the Enterprise, along with two other surviving Starfleet vessals, patrolled the Ceti Alpha system en guard for any potential attack by Xindi.

In 2165, Doctor Phlox left Denobula for the Ceti Alpha V colony with a new medical treatment for Jonathan Archer who was suffering memory loss due to interspatial parasites. Dr. Phlox was tailed by a Yridian who had been hired by the Xindi to discover the location of the secret colony. Shortly thereafter, the Xindi arrived in the system and attacked the Enterprise and two other Starfleet vessals. (ENT episode "Twilight")

It is not known what became of the colony, although it can be surmised that the Xindi probably attacked and destroyed it from orbit.