Plague

A plague, also known as an epidemic or a pandemic, was a widespread outbreak of an infectious disease.

In 2164, a plague struck Sauria in the 22nd century. 

In 2259, a plague struck Argylus, killing everyone over the age of thirteen. 

In 2266, Tomasina Laubenthal used one of the Malkus Artifacts to unleash a plague on Alpha Proxima II. 

In 2267, the Nisus colony was struck by a plague. 

In 2373, the Federation was struck by the Virogen plague. 

The Kevrata were ravaged by the bloodfire plague for many generations.