|years:||2164 2165 2166 2167 2168 2169 2170
|decades:||2130s 2140s 2150s 2160s 2170s 2180s 2190s|
|centuries:||21st century - 22nd century - 23rd century|
- The USS Archon makes first contact with the Betans of Beta III and is destroyed. 
- The USS Horizon makes first contact with the Iotians. 
- The USS Essex is caught in a storm over a Class M moon of Mab-Bu VI and destroyed. 
- On Cardassia Prime, a number of Hebitian tombs are unearthed. Inside the tomb is a vast amount of glor'ya-encrusted items. A Cardassian male named Dujonian steals the treasure and smuggles them off-planet. 
- Uttan Narsu, holding the rank of admiral, serves as sector commander while operating at Starbase 12.