53rd Street is a midtown cross street located in the New York City borough of Manhattan.

By the 2250s, Thomas and Dana Mitchell were residing in an apartment building on 53rd Street. During his friendship with Gary Mitchell, James T. Kirk visited the apartment numerous times with his friend, and he had happy memories of sharing an ale together and gazing upon the oil paintings of various cities from across Earth, such as Paris, London and Rome. In late 2265, Kirk visited the apartment to speak to the Mitchell's following Gary's death on Delta Vega. (TOS - My Brother's Keeper novel: Enterprise)

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