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An acid is a type of chemical compound. Strong acids can react violently, with a corrosive effect on metals or lifeform tissue.

A primitive but effective weapon system used acid against the Tarn on Torgu-Va. The descendants of Starfleet personnel stranded on the planet engineered special ducts into their tunnel dwellings so that enemy intruders, in this case, the Tarn, would be killed by corrosive injuries as acid flooded special underground areas. A telling aspect of the strain the conflict was that the acid releases were connected by ducts accessible only to children—if the area was attacked, they would be the last line of defense of their homes. (TNG novel: The Forgotten War)

The Horta had acid-producing glands which allowed them to burrow through rock. When a Horta was confused or scared, they sometimes lost control of their glands and squirted their acid around them, which could cause extensive damage to anything it happens to come into contact with. (TOS episode: "The Devil in the Dark"; DS9 novel: Devil in the Sky)

Following the destruction of Ceti Alpha VI, underwater volcanoes on Ceti Alpha V erupted, turning the planet's oceans into acid. This acid was potent enough to kill an Augment only seconds after full-body exposure. (TOS novel: To Reign in Hell: The Exile of Khan Noonien Singh)

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