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An antidote was a substance used to counteract the effects of poison.

In 2266, Leonard McCoy learned that the antidote to the plague that had stricken Argylus was genitum lars. (TOS comic: "Child's Play")

In 2267, Leonard McCoy provided the antidote for Akwood's syndrome to the Giant Brain. (TOS comic: "The Brain-Damaged Planet")

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