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Argylus was a class M planet located in the space of the galaxy's Alpha or Beta Quadrants. It was inhabited by an highly advanced humanoid civilization which was rated 17 on the industrial scale. They were so advanced that they were intellectually (but not emotionally or physically) mature by age three.

In 2259, Argylus was stricken by a plague which killed everyone over the age of thirteen. The children built their own civilization with a feudal-looking appearance, complete with castles, warlords, kings and robotic knights, but were unable to find a cure to the plague. One of the leaders, King Simon, began transmitting a distress call in the hopes of bringing to his world a starship capable of curing them. The other leader, Warlord Yago, had no hope that a cure would be found, and created games for his boys while they waited for death.

In 2266, the USS Enterprise, while en route to Zeta Centauri, received the transmission and arrived at Argylus, where James T. Kirk, Montgomery Scott, Hikaru Sulu and Christine Chapel beamed down to the surface. They were captured by robot chessmen and taken to Simon, who explained the situation to them. Leonard McCoy discovered a cure in the ship's databanks, which could only be found on Ominnus. While the Enterprise set out on the journey to that world, the landing party was captured by Yago, who first demanded that they hand over the cure, then imprisoned them in the dungeon prior to their execution. During an escape attempt, Kirk discovered that their rifles merely fired harmless light beams and that this was just one of Yago's games. Afterwards, the Enterprise returned, and the children were cured of the plague. (TOS comic: "Child's Play")

planets visited by the USS Enterprise (NCC-1701) during Captain Kirk's initial five-year mission (2265-2270)
various Aprilia IIICaporyGarrus
2265 EarthDraxis IITallyGamma Alpha VPollux IIStarbase 8 planetSector Vega 6 planetM-155Archernar IVDimorusTendarMestikoAlpha Ortelina VIIArronus VIIAldebaran IIIDelta Vega IStarbase 12VelleriusEarthEmpyreaTraveler's homeworldDukarNeesanAlgenib II
2266 Crucial-3VultraRobots' planetAngomaNuofoStaiVrexRigel XIIAlfa 177M-113Psi 2000M-3107Tlaoli IVAlpha Proxima IIArgylusOminnusEarthK-GAngiraBeta IINeesanKujalLunaBwujaFayoHerculaEarthKibo/NdoraNrakaAlpha 23-CNCP-137MobitaJodarrQuodarZartaFloe IMetamorphaInicrustMortiTerrellian IIVoodoo planetRiza homeworldMila XaKrugar III remnantArimaMazdaNumero UnoBeta CarinaeExo III1324-IV7348-IITantalus VMiri's homeworldPlanet QBeneciaElsinor H-25
2267 Taurus IIMakus IIIHydra Epsilon IIIXimega IIPerseus Arm planetoidYkoSalvumGrotusYkoTalos IVRifas-LAmusement Park planetHeitius VIICentaurus VTyrtaeus IIGothosBeta VITheta VII (Rell's world)Ramedes IIICestus IIIAlvaLazarus's planetZutotanium planetoidCygnet XIVEarthCanaraBeta IIIEminiar VIICeti Alpha VGamma 400TimshelOmicron Ceti IIIJanus VI7348-IIChandra IVOrganiaGatewayEarthDeneva • "the Frontier" • ModalaGamma XaridianStarbase 10Beta Mariotia IIIPyris VIIEarthPentam VGamma Canaris NNukoleeStyraLurotaGatewayIsis IIIMaaba S'JaCapella IVPollux IVVulcanMestikoNadorTactis IIBeta Nirobi IIPhygma IVM-370Argelius IIMerope IVMalurEulusDonico IIGamma Trianguli VIMasabaLekythosTyrtaeus IIShroud IVHalkaIxtoldeGamma Hydra IVCalydonBelmara IVTuran Tot Narut's planetMuddEarthAneher IIWezonvuNalaingMagna RomaBavaryaNeolithiaMythraRimilliaBabelGamma Canaris NVulcanNisusNarnel's WorldNeuralBeta Canzadia III
2268 Fornax IIGamma IITriskelionArgus XTycho IVCentaurusUsildeTheta VIISigni BetaTautee star systemAngrenaBeta Canzandia IIIMevinnaSigma Iotia IIXanviaXoxxaInquisitor's planetBeta ReticuliDelta VegaNalogenDelta VegaDelta Canaris IVAlnath IIAmmdonArretEkosEeiauoSivaoKahlessOmega IVEarthTheta Kiokis IIElasTroyiusTau Delta IXAmerindTranquility VIIMinos VEarthExo IIIT'nufoTortugaTriacusMarcos XIILowariaDreamers' planetSigma Draconis VIDireidiMedusaElcidar Beta IIIMinara IIOctavius IVBeta CabriniPegasus IVCareta VBeta XII-APlatoniusIzellEarthScalos M-317/Moore's PlanetBeta Aurigae IIIGamma Canaris NNew SanooraRhinegeltKalandan outpostBrellian IVPrastorDistrelTttnicktttnorAriannusCheronElba IISanctuaryGideonKolya
2269 Memory AlphaMerak IIArdanaPollux VAvalonBalkos IIINova Atar IIIVesbiusJanus VIPollux IILeora IVWaasertlaMygdalus IIICentaurusRaga's PlanetEdenTheta Tau VHolberg 917GBeta Niobe IIIExcalbiaSarpeidonCamus IIDuwamishEphrata IVSigma Niobe IIGatewayKrasniMaltos IVOrganiaKyrosBeta CastelliAnomalyAcademyArachnaeLyraBabelEpsilon Delta IVHeartlandMemory PrimeTalin IVSyhaar PrimeGatewayMantillesTaurus IIBeta Omicron Delta IIIMotherlodeMegas-TuTerratinSherman's PlanetThe StrandAarak IIIPhi XIUr homeworldVidenDengella IIEphrata IVGobi IIIPacificaGralafiLoren VArgoWaycrossPerryDelta Gamma IVDetente ITrefolgTrellisaneBeta CastelliHeloxBoaco VIJuram VVancadiaChyrellkaVeletus VPatria IPelos
2270 Janus VIPhylos IIVedala asteroidDramiaDramia IIArretLactra VIIBoqu IINGC 7332Delta Theta IIIPandroBriamosBelarius IVVelat Nol/R-836 IIN'caiStellaLiticiaGelladorn/R-775 ICenotaphVehtora IVMuldoonTaygeta VOkeanosBeta Omicron Delta IIIYoondriGatewayZeta GibraltarAndrosYusubEarth (alternate)SycoraxBira IIINjuraOmne's planetVoranRazarMercanAleriadAritaniYalboVulcanUnnamed Hoshan planetsTanisAragosAleph PrimeAleph IIIAntos IVTakoi homeworldEarthDenebiaVeneu IIKlondike VIIsitra ZeroPelosArchernar IVTalos IVPillagra/R-855EarthStarbase 12Tomarii
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