The Battle of the Mutara Nebula was the final engagement between James T. Kirk and Khan Noonien Singh, inside the Mutara Nebula, in 2285.

At the conclusion of the battle, Khan's USS Reliant was defeated by Kirk's USS Enterprise. However, Khan was able to detonate the Genesis device in a last attempt to kill Kirk and destroy the Enterprise. Fortunately, the Enterprise was able to escape thanks to the sacrifice of Captain Spock. (TOS movie: Star Trek II: The Wrath of Khan)

In 2372, Commander William T. Riker read up on every log and historical record pertaining to conflicts inside nebulae, including the Battle of the Mutara Nebula. (TNG eBook: A Sea of Troubles)

A simulation of the battle is a standard training scenario at Starfleet Academy for cadets to practice the necessary defensive measures when encountering a non-communicative ship and then practice starship combat in poor sensory conditions. (Star Trek: Starfleet Academy)

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