In 2268, around Stardate 4575.9 it was targeted by a fleet of linked units that sought to age its primary star with chronometric radiation to enter the supernova phase of its life so that they could harvest its stellar matter in order to refuel themselves and increase their numbers.
The crew of the USS Enterprise intervened before the units could succeed, disrupting their attempt by transmitting a jamming signal on the frequency on which the units communicated with each other. This disrupted their link with each other and made them shut down. Eventually Beta Reticuli's star would draw in the units and completely destroy them. (TOS comic: "Swarm")