Betelgeuse could refer to:
- Betelgeuse, the star
- Betelgeuse butter
- Betelgeusian
- Betelgeusian cigar
- Betelgeuse (sleeper ship)
- USS Betelgeuse (Antares-class)
- USS Betelgeuse (NCC-1822, Constitution-class)
- USS Betelgeuse (NCC-2520, Constellation-class)
- USS Betelgeuse (repair ship)
- USS Betelgeuse (Excelsior-class)
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