The Big Bang.

The Big Bang is a scientific colloquialism for the cosmological origin of the physical universe. By the 24th century, it was theorized that this event took place 15 billion years ago. (Last Unicorn RPG module: All Our Yesterdays: The Time Travel Sourcebook)

Federation cosmologists theorized that the Omega molecule existed just prior to the Big Bang, and may have been the trigger which caused the explosion. (VOY episode: "The Omega Directive") According to the Unified Field Theory, the universe at the time just before the Big Bang was a mass of matter and energy existing in ten dimensions; the explosion caused the six higher dimensions to collapse, leaving four readily accessible. (TNG - Maximum Warp novel: Forever Dark)

The event was witnessed by the crew of USS Voyager when Q and Quinn dragged the ship back from 2372. (VOY episode: "Death Wish")

From the first second through the tenth second after the Big Bang, the universe consisted of a quark-gluon plasma with an ambient temperature of more than 1 billion degrees Kelvin, with pressure waves of elemental particles. Elemental particles such as hadrons emerged and decayed, mostly during the first second after the Big Bang, and leptons emerged and decayed after the tenth second. (TNG novel: Indistinguishable from Magic)

The Big Bang occurred shortly before the formations of the Great Barrier and galactic barrier. (TNG novel: Q-Zone; TOS movie: Star Trek V: The Final Frontier; TOS episode: "Where No Man Has Gone Before", TAS episode: "The Magicks of Megas-Tu")

The Gravity's End proto-universe phenomenon showed that events similar to the Big Bang were either taking place or had taken place in parallel universes as well. Located near the Omega Maelstrom, Gravity's End was the only proto-universe phenomenon known to the United Federation of Planets. The phenomenon was known for its extremely high energy output, which exceeded that of 100 G-type stars. (TOS video game: Judgment Rites)

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