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Bio-neural circuitry was a technology which was incorporated into bioneural gel packs, which were first installed aboard Federation starships in the early 2370s. The circuitry was designed to supplement, and eventually replace, isolinear circuitry, as bio-neural circuitry could process information more efficiently, and therefore speed up computer response time. Intrepid-class starships, which entered service in 2370, were among the first to be equipped with bio-neural circuitry. (VOY episode: "Caretaker")

Bio-neural circuitry was also employed in ocular implants, replacing the obsolete Aroeste interfaces previously used. (TNG - Slings and Arrows eBook: The Insolence of Office)

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