Brennan could refer to:
- People:
- Brennan (USS Enterprise), a security officer aboard the USS Enterprise
- Brennan (USS Enterprise-E), a security guard aboard the USS Enterprise-E
- Brennan (Technician), a technician aboard the USS Trident
- Brennan Scott, a MACO aboard the Enterprise (NX-01)
- Brennan Scott (mirror), a MACO corporal aboard the ISS Enterprise
- James Brennan, a doctor aboard the USS Enterprise
- Liam Brennan, a 22nd century student on Earth
- Marcus Brennan, CO of the USS Sentinel
- Sarah Brennan, a Starfleet admiral
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