Brian (or Brien) could refer to:
- People
- Brian (20th century), a 20th century Human on Earth
- Brian (barfly), a 23rd century alien on Earth
- Brian (USS Cochrane), a Starfleet member in the 24th century
- Brian (horse), an 18th century horse
- Brian (nephew), a nephew of Montgomery Scott
- Bob Brien, an engineer aboard the USS Enterprise in the 2250s
- Brian Anderson, a Starfleet admiral, ex-husband of Doctor Katherine Pulaski
- Brian Connors, a computer specialist aboard the USS Enterprise-A
- Brian Cormack, chief of security aboard the USS Musgrave
- Brian Denham, a 23rd century resident of Tarsus IV
- Brian Ellis, a Starfleet counselor stationed at Starbase 22
- Brian Gunnell, a Starfleet officer during the Dominion War
- Brian Hayakawa, a crewman aboard the USS Starbound
- Brian Johnson, a member of Starfleet assigned to Starbase 375
- Brian Keane, a Federation casualty of the Borg Invasion of 2381
- Brian Kelley, a Starfleet starship security chief
- Brian O'Leary, an engineer aboard the USS da Vinci
- Brian Pelletier, a transporter chief aboard USS Voyager
- Brian Shelby, the father of Starfleet Admiral Elizabeth Shelby
- Brian Stuhlmacher, CO of the USS Bellerophon
- Brian Tatosky, a Starfleet Chief of Staff in the late 24th century
- Brian Victor, a Federation casualty of the Borg Invasion of 2381
- Brian Vogt Raymond (I), a relative of Clare Raymond
- Brian Vogt Raymond (II), a relative of Clare Raymond
- Brian Vogt Raymond (III), a relative of Clare Raymond
- Brian Whitley, a member of Starfleet Operations in the 2370s
- Real-life topics
- Brian Campbell, a Last Unicorn RPG author
- Brian McMahon, a Ships of the Line artist
- Brian Reber, an IDW Publishing artist
- Brian Seidman, a Strange New Worlds contest winner
- See also:
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