Burkhardt's disease is an degenerative and fatal illness that affects Humans.

Elias Vaughn's mother suffered from Burkhardt's disease and died when Vaughn was young. (DS9 - Mission Gamma novel: Twilight)

In an alternate timeline, Noonien Soong suffered from Burkhardt's disease. (ST - Myriad Universes novel: The Embrace of Cold Architects)

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