Calypso could refer to:
- Calypso (myth), a character from Greek mythology
- Calypso (Cousteau), an Earth ship by Human explorer Jaques Cousteau.
- Calypso (USS Enterprise-D), a captain's yacht assigned to the USS Enterprise-D.
- Calypso (USS Enterprise-E), a captain's yacht assigned to the USS Enterprise-E.
- USS Calypso (Hermes-class), a Federation scout
- USS Calypso (Merced-class), a Federation light cruiser.
- USS Calypso (Galaxy X-class)
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