Canopus could refer to:
- Canopus, a star and star system
- USS Canopus (NCC-1814), Constitution-class heavy cruiser
- USS Canopus (NCC-2523), a Constellation-class exploratory cruiser
- USS Canopus (Excelsior class), in service in 2378
- USS Canopus (repair ship)
- Canopus-class, a starship class
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