Chameleon could refer to:
- Lifeforms
- chameleon (animal), an Earth species notable for blending with its surroundings
- chameleon rose, a rose whose color is affected by emotions
- Calrissian chameleon, a reptile native to Calrissia
- Halkan water chameleon, a lizard native to Halka
- Chameloid, a shape-shifting species
- Starships and classes
- Chameleon (starship), a cargo ship belonging to Cyrano Jones
- Chameleon-class, a Federation cargo ship class
- Locations
- Chameleon (planet), fourth planet of the Harrapa system
- Chamaeleon, a Beta Quadrant constellation
- Alpha Chamaeleonis, a white giant star in Romulan space
- People
- Chameleon Boy, a.k.a. Reep Daggle, a member of the Legion of Super-Heroes
- Technology
- chameleon circuit, a personnel cloaking technology developed by the Breen
- chameleon device, an appearance-changing technology used by Gary Seven
- chameleon field, a probe cloaking technology used by the Chodak
- Real-world topics
- Digital Chameleon, a comic book coloring and inking studio
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