The cockroach was an insect native to Earth, which commonly bred in unsanitary conditions, and was notoriously hard to eradicate.

Roberta Lincoln had to deal with cockroaches in her East Village apartment in 1969. She found the lack of cockroaches one of the high points of the quarters found on a Constitution-class starship. (TOS novel: Assignment: Eternity)

In 2328, Gwen Jones compared Bajoran barrowbugs to cockroaches, except barrowbugs were larger and spat acidic venom. (ST - Terok Nor novel: Day of the Vipers)

Captain David Gold compared entrepreneur Rod Portlyn to a cockroach when the latter reemerged in 2377, several months after having been exposed for his unethical and amoral business practices. (CoE eBook: The Art of the Comeback)

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