Deep Space Station E-5 was a Federation Starfleet space station, a E-class starbase in operation in the late 24th century. It was located midway between Sector 001 and the Romulan Neutral Zone. In 2371, Ambassador Spock visited the station on his way to Earth from Romulus. At that time, at least six Starfleet vessels were assigned to or visiting the station. (ST - Spock: Reflections comic: "Issue 3")
- The station appears to be of a similar design to the Starbase 1 facility in use in the 2250s in the Kelvin timeline. This and the docking bay design may indicate that the station entered service in the 23rd century or earlier. Plus several alternate reality ships were docked with the station.
This is the only Federation starbase known to use the alphanumeric prefix "E".