Deneb could refer:
- Starships:
- USS Deneb (Aerie-class)
- USS Deneb (NCC-1826), a Constitution-class ship
- USS Deneb (Rigel-class)
- USS Deneb Clar, a Loknar-class ship
- A star system:
- Alpha Cygni system (the "true" Deneb), located near the Cygnus Reach
- Deneb Kaitos system (Beta Ceti), located in Sector 004
- Planets:
- Denebia
- Denebians, its inhabitants
- Deneb IV, located in the Alpha Cygni system and home to the Bandi
- University of Deneb, a university in the Alpha Cygni system
- Deneb Kaitos IV, located in the Deneb Kaitos system and home to the Deirr
- Deneb V, located in the Deneb Kaitos system and home to the Klaha
- Denebia
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