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Like a lethal bacillus coursing through the bloodstream of the galaxy, a fiendish master plan has spread death and terror across the 24th century—until two heroic captains risk everything to stamp out the evil at its source!
For more than a decade, since the very beginning of the starship Enterprise's mission, unknown enemies have unleashed a string of deadly biological weapons throughout the Alpha Quadrant, inflicting ghastly epidemics upon the Romulans, the Cardassians, the Bajorans, and even the Federation. Now, at long last, Captain Jean-Luc Picard joins forces with Captain Mackenzie Calhoun of the starship Excalibur to track down and confront the hidden architects of the plagues—and avenge the deaths of thousands!


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BenzBethBurgoyne 172Mackenzie Calhoun/QadrilCamboniChoSi CwanZolon DargDataElias FrobisherGeorge GarfieldGwixJanosEdward JellicoKapelKat'leenZak KebronDavid KendrowGeordi La ForgeRobin LeflerLodecMacaskillJoe MankowskiMaxwellMark McHenryMcKeanMonasteroJoe MorrisAlynna NechayevO'SheaMike PalumboPetronellaJean-Luc Picard/KwintMorgan PrimusThe ProfessorWilliam T. RikerSelaSelarElizabeth ShelbyShunaboSilverSoletaStonnGerrid ThulDeanna TroiVandelia/Vara SyndraWorfZeen
Referenced only
Mendan AbbisAroninBorg QueenJack CrusherRichard DaystromDiksonDiSpignoFalkarGazilloHendersonJayJack McNicolBruce Carmel MuddThaddius RikerThomas RikerLwaxana TroiWattanbeHoratio WrigleyNatasha Yar

Starships and vehicles

Andorian prison shipUSS Enterprise-Eescape podUSS ExcaliburUSS GrissomUSS IndependenceRomulan warbirdrunaboutshuttle


Alpha QuadrantArcharia IIIArgelius IIDaystrom StationEarthKara'sNarobi IISan FranciscoTen-ForwardThul SphereWrigley's Pleasure Planet
Referenced only
Bajoran wormholeCardassiaDanterDeep Space 4Delta QuadrantDemilitarized ZoneEstarcion IVHellMarsRisaRomulusStarbase 18Terok NorTopekaXenex

Races and cultures

Referenced only

States and organizations

Daystrom InstituteStarfleetThallonian EmpireUnited Federation of Planets

Science and technology

animalBendii syndromeblack holeblasterbombbonebulletchronometercircuitcloaking devicecomm unitcommunicatorcryo-mistcyborgdermaplastdisruptorDouble Helix virusDyson sphereGuardian of Foreverheadacheheartholodeckhologeneratorhologramholo unithypersonic showerisolinear chiplightmicrochipmicroscopemusclenaniteOmega 9phaserphoton torpedoplasma torpedopsychic backlashreplicatorscannersensorskin graftsupernovatimetoothtranspondertransportertricorderturboliftVenus drugwarp coreZynterian camouflage field

Ranks and titles

admiralcaptaindistributorensignheroimzadiprofessorweapons runner

Other references

asteroid fieldbaseball batbeanbagbicentennialcatwalkcatdaggerdaydevilDominion Warespionagefinger cymbalgloveGreat Bird of the Galaxygrozitkatraklaxonknifelatinummoneymonthpasteboardphilosophypipplaying cardpon farrPrime DirectiveResolution of Non-Interferenceropescalpelsex aidshampooshawlsickbayStone AgeswordtennistigerTolasian night slicerVulcan nerve pinchweaponwhipyear



  • The Double Helix series was a Next Generation storyline that featured each installment crossing over with another franchise series. "Double or Nothing" in particular crossed TNG with Star Trek: New Frontier.



published order
Previous novel:
TNG numbered novels Next novel:
The First Virtue
Previous novel:
Double Time
NF Stories Next novel:
The Quiet Place
Previous novel:
Double Helix
Next novel:
The First Virtue
chronological order
Previous Adventure:
What You Leave Behind
Chapters 11-15
Pocket Next Adventure:
The Left Hand of Destiny, Book One
Previous Adventure:
The Human Factor
Voyages of the
USS Enterprise (NCC-1701-E)
Next Adventure:
I, Q
The above chronology placements are based on the primary placement in 2376.
The Pocket Books Timeline places events from this story in one other timeframe:
Previous Adventure:
Seven Years Earlier
Next Adventure:
Star Trek: New Frontier publications and stories
Novels House of CardsInto the VoidThe Two-Front WarEnd GameMartyrFire on HighOnce BurnedDouble or NothingThe Quiet PlaceDark AlliesExcalibur (RequiemRenaissanceRestoration)Cold WarsBeing HumanGods AboveStone and AnvilAfter the FallMissing in ActionTreasonBlind Man's Bluff
Short stories and novellas "Death After Life" • No Limits ("Loose Ends" • "All That Glisters..." • "Waiting for G'Doh, or, How I Learned to Stop Moving and Hate People" • "Lefler's Logs" • "Alice, on the Edge of Night" • "Revelations" • "Turning Point" • "'Q'uandary" • "Oil and Water" • "Singularity" • "The Road to Edos" • "A Lady of Xenex" • "Making a Difference" • "Performance Appraisal" • "Redemption" • "Out of the Frying Pan" • "Through the Looking Glass" • "A Little Getaway") • "Stone Cold Truths" • "Pain Management" • "Cutting Ties" • "Homecoming"
eBooks The Returned, Part 1The Returned, Part 2The Returned, Part 3 Comics Double TimeTurnaround ("Part I" • "Part II" • "Part III" • "Part IV" • "Part V")
Omnibuses New FrontierPrometheansTurnaround German omnibuses KartenhausZweifrontenkrieg

External link