The Drek'la are a species whose members all dwell in space aboard ships they either take possession of from others or those they find derelict that can be repaired. Due to their circumstances, population numbers of Drek'la are only a few thousand.

In 2373, the Drek'la worked with renegade Cardassians to conquer the Tiffnaki homeworld, a planet rich in latinum. (DS9 - Rebels novels: The Conquered, The Courageous)

Benjamin Sisko and the crew of the USS Defiant were later able to help the Tiffnaki force the Drek'la and the Cardassians off the Tiffnaki planet. (DS9 - Rebels novel: The Liberated)

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