Ebola was a disease native to the lifeforms of the planet Earth, originating from the African continent. It was a severe, multi-system viral syndrome, similar to yellow fever and Vulcan bebonea. Sherman's Plague was also compared to ebola upon its discovery in the year 2376. (SCE eBook: Oaths)
In the aftermath of World War III, Colonel Phillip Green was killed by a weaponized strain of ebola, which Flint (using the identity of Jerome Drexel) had deployed against Green and his staff. (ST short story: "The Immortality Blues")