The Federation-Cardassian Treaty of 2366 was a treaty between the United Federation of Planets and the Cardassian Union that ended the Federation-Cardassian War.

In 2367, Benjamin Maxwell, believing the Cardassians had signed the treaty to buy time to rebuild and regroup their forces, launched a series of attacks on Cardassian targets until he was pursuaded to stop by Miles O'Brien. (TNG episode: "The Wounded")

In 2369, Benjamin Sisko reminded himself of the treaty when he first met Skrain Dukat aboard Deep Space 9. (DS9 episode & novelization: Emissary)

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