Federation-Klingon War may refer to:
- the Four Years War of the 2250s
- the Federation-Klingon War of 2256
- the Federation-Klingon War of 2267
- the Federation-Klingon War of 2269
- the Federation-Klingon War of 2285
- the Federation-Klingon Cold War
- the Federation-Klingon War of 2372-2373
- the Federation-Klingon War of 2405-2410
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