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The Federation-Tzenkethi border was the border between the United Federation of Planets and the Tzenkethi Coalition.
Helaspont Station was near the border. (ST - The Lost Era novels: Serpents Among the Ruins, One Constant Star)
In 2362, the USS Okinawa patrolled the border. (ST - Typhon Pact novel: Rough Beasts of Empire)
In 2385, Federation President Pro Tempore Ishan Anjar sent several starships to the Tzenkethi border. (DS9 novel: Sacraments of Fire)