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A friendly reminder regarding spoilers! As always, the expanded Trek universe is in a period of major upheaval with the continuations of Strange New Worlds and Prodigy, the advent of new eras in gaming with the Star Trek Adventures RPG and Star Trek Online, as well as other eventful releases such as Section 31, the ongoing IDW Star Trek comic and spin-off Star Trek: Defiant. Therefore, please be courteous to other users who may not be aware of current developments by using the {{spoiler}}, {{spoilers}} OR {{majorspoiler}} tags when adding new information from sources less than six months old (even if it is minor info). Also, please do not include details in the summary bar when editing pages and do not anticipate making additions relating to sources not yet in release. THANK YOU

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Memory Beta, non-canon Star Trek Wiki

Finalkill is the term used to describe unchangeable, absolute death in the 31st century.

In that time frame, transreplication technology, future medicine and hologram technology can extend life almost indefinitely. When a lifeform irrevocably dies and can't be saved by any of these methods, they are said to have been finalkilled. (DTI eBook: The Collectors)