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Fungus (plural: fungi) were a type of eukaryotic organism that included mushrooms, yeasts, and mold. Earth based fungi were noted for sharing a large amount of DNA with humans.

On Tarsus IV, seeds imported from Epsilon Sorona II interacted poorly with the soil, spawning a fungus that destroyed most of the planet's food supply. In the years following the crisis a great deal of work went in to prevent similar fungal infections from occurring elsewhere. (DSC novel: Drastic Measures).

Abaris natives had a fungal-based physiology. (TOS comic: "Aberration on Abaris")

On Direidi, a type of fungus is used to distill sparkling wines. (TOS novel: How Much for Just the Planet?)

Fungus could be used in the manufacturing of Ketracel-white. (DS9 episode: "Statistical Probabilities")

Doctor Mora Pol once suggested exposing an infant Changeling to fungi in order to train it to assume different shapes. (DS9 episode: "The Begotten")

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