The Great Crash of 09 was an economic disaster of Orion history.
In reference stardate 2/0902, three Orion corporations were implicated in efforts to sabotage the Babel Conference of 2267. In response, trade with the Federation dropped, triggering the Great Crash, and all three went bankrupt. (FASA RPG - The Orions modules: Book of Common Knowledge, Book of Deep Knowledge)
Meanwhile, Coridan's admission to the Federation hit local Orion dilithium smuggling operations hard, depriving them of a valuable resource. (Last Unicorn RPG module: All Our Yesterdays: The Time Travel Sourcebook)
Orion trade was also weakened across the Klingon Neutral Zone and the Triangle. This had severe effects on Orion worlds. (FASA RPG - The Orions modules: Book of Common Knowledge, Book of Deep Knowledge)