Grissom could refer to:
- People:
- Gus Grissom, Virgil Ivan Grissom, aka "Gus"
- Starships and vehicles:
- USS Grissom (NCC-638), an Oberth-class ship
- USS Grissom (NCC-1545), a Miranda-class ship
- USS Grissom (NCC-59314), an Oberth-class ship
- USS Grissom (NCC-42857), an Excelsior-class ship
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