Hoffman could refer to:
- People
- Hoffman (paramedic), a crewman on the USS Enterprise
- Hoffman (USS Voyager), a crewman on the USS Voyager
- Marshall Hoffman, a 23rd century Starfleet officer
- Evelyn Hoffman, a 24th century Starfleet officer
- Locations
- Real-world topics
- Nina Kiriki Hoffman, a co-author of a Star Trek: Voyager novel, Echoes
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