In the mirror universe, the ISS Runabout (NCC-72004) was a Terran Empire spacecraft, an Imperial Starfleet Danube-class runabout in service in the 2400s decade. (STO - Cardassian Struggle missions: "Defend the Beta Ursae Sector Block", "Crack in the Mirror")
In 2409, the Runabout was part of the Terran fleet attacking shipping lanes in the Alpha Quadrant. The civilian traffic was defended by Federation Starfleet. (STO - Cardassian Struggle mission: "Defend the Beta Ursae Sector Block")
In the same year, the ISS Runabout was one of three Danube-class ships carrying silithium towards the Bajoran wormhole. The leader of the Terran invasion, Captain James O'Brien, sought to redirect the wormhole into the mirror universe, where more of his fleet lay in wait. The three runabouts were apprehended by a Starfleet vessel and destroyed alongside O'Brien and his flagship, the ISS Molly. (STO - Cardassian Struggle mission: "Crack in the Mirror")
|Federation Starfleet||Acheron • Amazon • Brahmaputra • Cam • Danube • Elestan • Euphrates • Gander • Ganges (I) • Ganges (II) • Genesee • Glyrhond • Holana • Hudson (I) • Hudson (II) • Inwood • Irrawaddy • Lorus • Marquand • Mattingly • Mekong • Mississippi • Missouri • NCC-70310 • NCC-73918 • Nile • Orinoco • Platte • Rio Grande • Rubicon • Seine • Shenandoah • St. Lawrence • Senha • Styx • Sungari • Taaj • Tecyr • Tiber • Volga • Yangtzee Kiang • Yolja • Yukon • Zambesi|
| Terran Imperial Starfleet|
|Delaware • Hydaspes • Runabout • Vistula|
- All three runabouts in "Crack in the Mirror" were named ISS Runabout.
- With the launch of the STO video game: Legacy of Romulus, the ISS Runabouts were replaced by the ISS Delaware, ISS Hydaspes and the ISS Vistula.