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The International Space Station, or ISS, was an early Earth space station that was in operation during the 20th and 21st centuries.

The ISS represented one of humanity's first international efforts to explore space - with NASA (United States of America), the Russian Federal Space Agency (Russia), the Japan Aerospace Exploration Agency (Japan), the Canadian Space Agency (Canada), and the European Space Agency all participating in the project.

The first module of the space station was put into orbit in November 1998. Construction was delayed by the destruction of the space shuttle Columbia. However construction resumed, and during the 21st century the space station was expanded considerably. (Star Trek: Enterprise credits sequence)

Shortly after the founding of Starfleet in the early 21st Century, Voula and the Core beamed aboard the ISS as a waypoint, before beaming over to a Romulan ship further out in the Solar System. (ST performance: Star Trek Live)

The ISS was one of a number of images presented to Jonathan Archer after he and the crew of the Enterprise (NX-01) repaired the damage to the timeline. (ENT episode: "Storm Front, Part II")

Images of the ISS were among the USS Enterprise computer files accessed by the Talosians in 2254. (TOS episode: "The Cage")

Benjamin Sisko had a model of the ISS in his office aboard Deep Space 9. (Star Trek: Deep Space Nine set decoration, ST reference: The Star Trek Encyclopedia)