In the 2350s, her niece often stayed in her house while her parents were away.
In 2377, she contacted Starfleet asking them to tell the USS Voyager that she would like to contact her niece. Starfleet informed Seven and she contacted her aunt soon afterwards. The two of them discussed Seven when she was a little girl. Irene told her that she was "the most stubborn six-year-old she'd ever met" and that it was wonderful to see her again. (VOY episode: "Author, Author")
As Magnus and Erin had embarked on their independent research mission to study the Borg on Stardate 32611 in 2353, this was the first time that Irene had seen her niece in almost 25 years. (VOY episode: "Dark Frontier")
By 2381, Irene had the incurable progressive neurological disease Irumodic Syndrome and was slowly dying. Seven noted that she was the only thing to bring her comfort and watching her condition degrade was like observing a slow motion assimilation. (ST - Destiny novel: Mere Mortals)