Kent State University was an institution of higher learning in Kent, Ohio on Earth, founded in 1910. Kent State was infamous for an incident on May 4, 1970, when troops of the Ohio National Guard fired weapons at students protesting the war in Southeast Asia, killing four and wounding nine.
Curtis A. Wellborn, a student at Illinois State University, evoked the tragedy at Kent State several months later, during a similar tense confrontation between student protesters and armed Guardsmen on the ISU campus. (TOS - Star Trek: Assignment: Earth comic: "My Name Is Legion")
Some time before 2372 scientists at Kent State performed an experiment where they duplicated a single piece of matter via a divergence of subspace fields. These scientists were unable to successfully do the same with antimatter. Starfleet Captain Kathryn Janeway had been aware of the experiment and results. (VOY episode: "Deadlock")