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The Kentucky Derby was a famed horse race, first held in 1875 in Kentucky on Earth, and continuing annually into the late 23rd century. The Kentucky Derby, along with the Preakness and the Belmont, make up the Triple Crown.
In 2296, while being held by Romulan soldiers on planet Obsidian, Leonard McCoy spoke at length about the sport of horse racing in order to forestall his execution. (TOS novel: Vulcan's Forge)