Lester could refer to:
- Lester, a cousin of Spock
- Lester (doctor), a 24th century doctor
- Lester Foster, a lieutenant aboard USS Voyager
- Lester Johnson, a friend of Benny Russell
- Lester Lee, a pseudonym of D.W. "Prof" Smith, writer of Captain Proton adventures
- Lester Levesconte, a 24th century Starfleet officer
- Janice Lester, a 23rd century archeologist
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