Lewis could refer to:
- People:
- Lewis (Commander), a Starfleet officer in the 24th century
- Lewis (engineer), an engineer aboard the USS Enterprise-D
- Lewis (nurse), a nurse aboard the USS Enterprise-D
- Lewis (Starbase 27), a Starfleet officer on Starbase 27 in the 23rd century
- Lewis (subengineer), a female engineer aboard the USS Enterprise
- Lewis (USS Enterprise), a male crewmember aboard the USS Enterprise
- Lewis Baker, an engineer aboard the USS Enterprise
- Lewis Carroll, a 19th century novelist and poet
- Lewis Chang, a casualty of Earth's Vietnam War
- Lewis Rosenhaus, CMO of the USS Constellation
- Lewis Zimmerman, inventor of the Emergency Medical Hologram
- Fenton Lewis, a 24th century Starfleet ambassador
- Meriwether Lewis, an explorer of western America
- Luis, an engineer aboard the Xhosa
- Starships and vehicles:
- Lewis (shuttlecraft), a shuttle attached to USS Enterprise-D
- Lewis and Clark, a Belle Terre Conestoga-class colony ship
- UNSS Lewis and Clark, a 21st century Aventeur-class sublight explorer
- USS C. Lewis (NCC-1718)
- USS C. Lewis, a 24th century Galaxy-class explorer starship
- USS Lewis (cutter), a 23rd century cutter starship
- USS Lewis and Clark, a 24th century Federation starship
- Locations
- Lewis Colony, a settlement in the Alpha Centauri system
- Lewis Elementary School, an Earth institution
- Other topics
- Lewis and Clark Corps of Discovery Cross, a Federation award
- Real-life topics:
- Bob Lewis, a.k.a. Bob Lubbers, a DC Comics artist
- See also : Louis
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