Lisa could refer to:
- People
- Lisa, a communications officer on the USS Enterprise
- Lisa Babitz, CMO of the USS Sagittarius
- Lisa Bates, a Tal Shiar operative serving aboard the USS Enterprise
- Lisa Bennit, chief geologist of the USS Enterprise
- Lisa Cochrane, the mother of Zefram Cochrane
- Lisa Del Colle, CO of the USS Republic
- Lisa Cusak, CO of the USS Olympia
- Lisa abn Dari, a member of the Federation Security Council
- Lisa Elgenn, a farmer on Sheridan's World
- Lisa-Karen Hawkins, a casualty of the Borg Invasion of 2381
- Lisa Iovino, a pediatrician aboard the USS Enterprise-D
- Lisa Jay, chief of the Fountainworld Tourist Bureau
- Lisa Marchant-Smith, an associate researcher at Deep Space Research Facility 39
- Lisa Neeley, a security officer aboard Deep Space 9
- Lisa Neeley (mirror), a Terran Rebellion member aboard Terok Nor
- Lisa Putman, night shift communications officer aboard the USS Enterprise
- Lisa Richards, a science officer aboard the USS Enterprise
- Lisa Tremaine, CMO of the USS Hastings
- Lisa Washington, a science officer aboard the USS Cochise
- Objects
- Mona Lisa, a painting by Leonardo da Vinci
- Real-world topics
- Lisa Kolek, a FASA artist
- Lisa Sullivan, a NF short story author
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