- Superworm
- Supply Woes
- Supply ship
- Support beam
- Support carrier
- Support cruiser
- Support frigate
- Supreme Arbiter of the Alliance
- Supreme Council Hall
- Supreme Council of Earth
- Supreme Court of the United Federation of Planets
- Supreme Magisterial Authority of Triex
- Supreme Medal of Honor
- Supreme Palace
- Supreme Regent of Vulcan
- Supreme Ruler
- Supreme Soul
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- Supu ya kiazi
- Sur
- Sur Le Mer Coucher
- Sura'tara
- SuraKahr
- Surah
- Surak
- Surak's Analects
- Surak's Peak
- Surak's Reforms
- Surak's Soul
- Surak (disambiguation)
- Surak (mirror)
- Surak (science vessel)
- Surak (ship)
- Surak (shuttlecraft)
- Surak I
- Surak II
- Surak Memorial
- Surak class
- Surakian
- Surakian Peace Prize
- Surakian logic
- Suraktic Method
- Sural
- Suran
- Surani
- Suranyi
- Surata IV
- Surax
- Suraya class
- Surek (24th century)
- Surface-to-space phasers
- Surface 92
- Surface Tension
- Surface operations blacks
- Surgeon
- Surgeon-commandant
- Surgery
- Surgh
- Suri
- Surjada
- Surjan
- Surn
- Surname
- Surok
- Surplus Depot Z15
- Surprise
- Surprise!
- Surprise II
- Surraben Antok
- Surrender
- Survan
- Surveillance (CA-13)
- Surveillance satellite
- Survey II
- Survey plane
- Survey shuttlecraft
- Survey squadron
- Survey team
- Survey vessel
- Surveyor
- Survival
- Survival Instinct
- Survival Strategies
- Survival kit
- Survival of the Fittest
- Survival of the Fittest, Part One
- Survival of the Fittest, Part Two
- Survival training
- Survivalist
- Survivor
- Survivors
- Survivors Corporation
- Surya
- Susan
- Susan (disambiguation)
- Susan Anderson
- Susan Brown
- Susan Drew
- Susan Haznedl
- Susan Hyatt
- Susan Kearney
- Susan Ling
- Susan Lomax
- Susan Nuress
- Susan Phillips
- Susan Ross Moore
- Susan S. McCrackin
- Susan Shwartz
- Susan Weinstein
- Susan Wright
- Susanna Leijten
- Sushi
- Susie (disambiguation)
- Susie Beech
- Susna
- Suspect
- Suspect (STO)
- Suspicions
- Suspiria
- Suspiria's array
- Sustainer
- Sustenance
- Susurrora
- Sutak's Fifth Principle
- Sutek
- Sutherland
- Sutherland (shuttlecraft)
- Sutherland class
- Sutler
- Sutor Mountains
- Sutorox
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- Suurok class
- Suus Mahna
- Suuuvef
- Suv'batleth
- Suvak
- Suven
- Suvian snapping eel
- Suvuw
- SuvwI'Qeh class
- Suwarin
- Suzan Bagdadi
- Suzanne Forrestor
- Suzanne Milton
- Suzette Ling
- Suzi Powell
- Suzie
- Suzie Finneran
- SvaD
- Svaath Magodin
- Svala
- Svala system
- Sven
- Sven "Buttercup" Hansen
- Sven Havoc (23rd century)
- Sven Havoc (24th century)
- Sven Jonsson
- Sven van Anling
- Svenquist O'Shea
- Svetlana Gredenko
- Svoboda
- Svoboda II
- Svon
- Swagger stick
- Swahili
- Swallow Nebula
- Swamp King
- Swamp King at Sunset
- Swamp eel
- Swamp tuber
- Swan
- Swarm
- Swarm (STO)
- Swarm (comic)
- Swarm (disambiguation)
- Swarm (ship)
- Swarm class
- Swarm drone
- Swarmer
- Sweden
- Sweeney
- Sweeney (bounty hunter)
- Sweet Song
- Sweet Sorrow
- Sweetfruit
- Swelvak
- Swenson
- Swenson (disambiguation)
- Swift (CL-14)
- Swift (disambiguation)
- Swift Solaria
- Swift Solaria class
- Swifts
- Swiftwing class
- Swimming
- Swimming pool
- Swindle! The Sale of Fraudulent Science
- Swing
- Swiss Army knife
- Swiss cheese
- Swiss on rye
- Switzerland
- Swooper
- Sword
- Sword Oath
- Sword of Damocles
- Sword of Damocles (object)
- Sword of Kahless
- Sword of Kahless (mirror)
- Sword of Mar'na F'ullhy
- Sword of S'task
- Sword of Sajik
- Sword of the Raptor Star
- Swordhunt
- Sworn Warrior of the Empire of Thrace
- Sxottlan
- Sya
- Syba Avtra
- Sybaron
- Sybo
- Sybok
- Sybok (Kelvin timeline)
- Syclarian
- Sycorax
- Sydney
- Sydney (Lieutenant)
- Sydney (disambiguation)
- Sydney Elliot
- Sydney Stockman
- Sydney class
- Syggelos
- Sygnia
- Syjin
- Sykora
- Syladdo
- Syletir module
- Syliss
- Sylix
- Syllerran I
- Syllerran II
- Syllerran III
- Syllerran IV
- Syllerran Rift
- Syllerran V
- Syllerran sector
- Syllerran system
- Sylorn
- Sylshessa
- Sylshessa (planet)
- Syltrack
- Sylva
- Sylvan
- Sylvana Kadohata
- Sylvia (Tombstone)
- Sylvia Tilly
- Sylvia Tilly (mirror)
- Symbalene blood burn
- Symbiont (Hephaestan)
- Symbiont pool
- Symbiosis
- Symbiosis (disambiguation)
- Symbiosis (episode)
- Symbiosis Evaluation Board
- Symbiosis Institute
- Symbokovech
- Symmetrists
- Sympathy
- Symphony Alpha
- Symphony for the Damned
- Syn lara
- Synaptic pattern displacement
- Synchrinity
- Syncrete
- Synder Nogar
- Synesthesia
- Syng II
- Syngreal
- Synod
- Synta Kayanil
- Syntagus Theluv
- Synth
- Synth destroyer
- Synth frigate
- Synthale
- Synthehol
- Synthesis
- Synthetic Revolt
- Synthetic dilithium
- Synthetic fiber
- Syntho-nummies
- Synthotonin
- Synton
- Synton IV
- Syracuse
- Syracuse (disambiguation)
- Syral
- Syrath
- Syrath (disambiguation)
- Syrath (planet)
- Syrenya
- Syrenya Development Company
- Syria Planum
- Syringe
- Syrinx (disambiguation)
- Syrinx (free starship)
- Syrinx (ship)
- Syrinx III
- Syrrannite
- Syrrannite Reformation
- Syrup of squill
- System-5 disruptor
- System 1324
- System 330
- System 6-15
- System 6-23
- System 7348
- System C-71
- System J-356
- System J-361
- System Loski
- System p Eridani
- System qetlh'agh
- System qovo
- System qu'neD
- System qvaQ
- Systems of Logic
- Systra
- Syto bean
- Sytok
- Syvak
- Syvar
- Szaastul
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- Szamra
- Szasz
- Szeket
- Szlar'it
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- São Paulo
- T'Acog
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- T'Agga
- T'Ana
- T'Andorla