Lucy or Lucille could refer to:
- People
- Lucy (Assistant), assistant to Yrolla Gari on Cestus III
- Lucy (Maidenshore), common law wife of Billy Maidenshore
- Lucy (smuggler), a crewperson aboard the USS Enterprise
- Lucy (The Final Reflection), assistant to Thomas Jackson McCoy
- Lucy D'Odorico, a lieutenant aboard the USS Aventine
- Lucy Pogue, an Earth juvenile with a criminal record
- Lucy Quinones, a security specialist on Belle Terre
- Lucy Reynolds, daughter of Charlie Reynolds
- Lucy Robinson, sister of B.G. Robinson
- Lucille Davenport, a holodeck character played by Kathryn Janeway
- Lucille Harewood, daughter of Thomas and Rima Harewood
- Lifeforms
- Old Lucy, a giant crustacean on Okeanos
- Other subjects
- I Love Lucy, a 20th century TV series
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