Luke could refer to:
- People
- Luke (Ransom Castle), a crewman aboard the freighter Ransom Castle
- Luke (Trinh's husband), a 23rd century archeologist, husband of Mai Duyen Trinh
- Luke Rayner, CO of the Constitution-class USS Alexander
- Roberta Luke, a Section 31 operative aboard USS Voyager
- Literature
- Book of Luke, a book in the Bible from Earth
- Real-world topics
- Luke McDonnell, Marvel Comics penciler
- Luke Sparrow, IDW cover and interior comic artist
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