Lupus could refer to:
- Locations:
- Lupus constellation
- Lupi stars and systems
- Lupus constellation
- Starships and vehicles:
- USS Lupus
- RIS Lupus (Romulan Snipe-class)
- RIS Lupus (Romulan Shrike-class)
- Lupus (ship)
- Lupus 2
- Lupus 7
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