McDonald, MacDonald or Macdonald could refer to:
- People
- MacDonald (Doctor), male medical officer on an Excelsior-class starship
- Macdonald (Doctor), female Starfleet Academy instructor
- McDonald (transporter chief), transporter chief of the UESPA starship Yellowjacket
- Benjamin McDonald-Jefferies, an engineer at New Bell Laboratories
- Christine MacDonald, CO of the USS Pathfinder
- Ksanna MacDonald, a child born on Sheridan's World
- L.M. McDonald, a science operations officer aboard the USS Enterprise
- Thadeus MacDonald, co-administrator of the colony on Sheridan's World
- Starships and vehicles
- USS MacDonald, an Ambassador-class light cruiser
- Real-world topics
- Scott MacDonald, a TNG, DS9, VOY, and ENT actor
- Douglas O. McDonald, a voice actor in Klingon Academy
- Star Trek: The Motion Picture McDonald's Happy Meal Comic Adaptations, a series of TOS comic strips
- McDonald's, a 20th and 21st century restaurant chain
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