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The Manheim Event was a disruption of time caused by Dr. Paul Manheim's experiments with time. The event occured in 2364 and caused several loops in time across a vast swath of the Federation. (TNG episode: "We'll Always Have Paris")
The event so disrupted Marion Dulmur's life, he hunted Manheim down and confronted the doctor about the lives he had destroyed. (DTI novel: Watching the Clock)