Margaret could refer to:
- People
- Margaret Atwood, 20th century author of Life Before Man
- Margaret Carsen, a division head at Chandley Works, Ltd.
- Margaret Chapman, wife of Dr. Paul Chapman
- Margaret C. Clark, CO of the USS Republic
- Margaret deSilva, a biologist for Project Nursery
- Margaret Houlihan, a relative of Clare Raymond
- Margaret Hurn, a division head at Smith & Smythe Motor Works, Ltd.
- Margaret Issen, a farmer on Sheridan's World
- Margaret Kuykendall, a commodore in Starfleet Intelligence
- Margaret Leary, a security officer aboard the USS Enterprise-E
- Margaret Mitchell, a casualty of the Borg Invasion of 2381
- Margaret Mullin, a girlfriend of Jonathan Archer
- Margaret O'Sullivan, a 24th century Federation pirate
- Margaret Sinclair-Alexander, a 24th century Commander-in-Chief of Starfleet
- Margaret Swenderson, a casualty of Earth's Vietnam War
- Margaret Thatcher, a Prime Minister of the United Kingdom
- Margaret Verliek, a division head at Starwide Merchants
- Margaret Wallabee, wife of USS Courageous CO Fitzsimmons Wallabee
- Ann-Margret, a 20th and 21st century American actor and singer
- Starships
- USS Dr. Margaret Flinn, a Federation hospital ship
- Margaret Mead Center, part of New York's Museum of Natural History
- Real-world topics
- Margaret Clark, a Pocket Books editor
- Margaret Wander Bonanno, a TOS and TLE novelist
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