McAuliffe could refer to:
- McAuliffe (NCC-1647/11), a Class-F shuttlecraft assigned to the USS Farragut
- McAuliffe (class H shuttlecraft), a Class-H shuttlecraft assigned to the USS Enterprise-B
- USS McAuliffe, a Federation Starfleet starship active in the 24th century
- Christa McAuliffe, a 20th century human woman and astronaut
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