In 2266, when the Federation starship USS Enterprise visited this star system, they were attacked by Hytaran spaceships who thought they were Nuofons. James T. Kirk attempted to visit Nuofo as a mediator, but his exploration rocket was shot down in space. A four-man landing party then beamed down to Nuofo, but they were apprehended.
When more ships attacked the Enterprise, Kirk launched an all-out assault on Nuofo. An assault force landed in the capital city. Irf surrendered and agreed to host a peace conference. Peace was short-lived, however, when Nuofo's city was suddenly struck by missiles from a mutual enemy, Desta. After the Enterprise drove off a Destan fleet, both governments agreed to hold democratic elections and were reunited under new President Juf. (TOS comic: "The Third Party")