Orb of Destruction

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Spoiler warning: Plot and/or ending details follow: The following content contains spoilers!

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The Orb of Destruction was a 24th century Bajoran religious artifact, an orb, also known as a Tear of the Prophets, gifted to the Bajorans by the godlike Prophet beings of the Bajoran wormhole. In the 2370s decade, the Orb of Destruction was a counterpart or complementary to the Orb of Creation. (ST - IDW - The Red Path comic: "Part 4")

History and specifics

The Tears of the Prophets leaving the Celestial Temple.

The orbs appeared to the Bajorans over the past ten thousand years. By the year 2369, nine orbs were known to exist. (DS9 episode & novelization: Emissary)

In the aftermath of the Dominion War, Starfleet had assigned Lieutenant junior grade Shaxs Drazon to locate all of the Orbs. Shaxs confirmed the existence of ten Orbs by 2377, theorizing that the missing Orbs had been taken off Bajor by the Cardassians. (ST - The Red Path comic: "Part 1")

Under undivulged circumstances, the Orb of Destruction wound up in Emperor Kahless's possession. Seeing the Orb as a chance to continue the deicide he'd started in his original lifetime, Kahless travelled to Sarkadesh, threatening to turn the Orb against the planet unless the Shapers built him a weapon that could channel the Orb's power. Cowed, the Shapers built a "godkiller array" into his flagship, the Quv vo'Kahless. (ST - Godshock comics: "Part 2", "Part 4", "Part 5")

Among Kahless' early victims included the Organians, out of revenge for the Organian Peace Treaty, and Gary Mitchell. (ST - Pleroma comic: "Part 1" & ST comic: "A Perfect System")

The Prophets restored Benjamin Sisko to corporeal existence to retrieve the Orb and counter Kahless' threat. After taking captaincy of the USS Theseus, Sisko witnessed Kahless turn his weapon on Branchers in the Hephaestus Nebula. (ST - Godshock comic: "Part 1")

The attack having absorbed a Brancher's ability to feed off a planet, Kahless killed Kazis IX to recharge his weapon. (DFT comic: "Issue 2")

When Sisko came to Qo'noS, Kahless, his identity as the killer still hidden, denied the Theseus passage to Sarkadesh. Resuming his crusade, Kahless' next target was the God City of the T'Kon. Due to the interference of the Theseus though, Kahless failed to kill the God City, rousing it back into action. With the Quv vo'Kahless damaged, Kahless retreated back to Qo'noS. (ST - Godshock comics: "Part 2", "Part 4", "Part 5")

On the Day of Blood, Kahless, anticipating that Starfleet would try and stop, had Alexander Rozhenko guard his throne. Facing off against Sisko in battle, Kahless immobilized the captain with the Orb of Destruction before he fatally stabbed a repentant Alexander from behind. On the cusp of victory however, the USS Theseus fired the energies of the Orb of Creation at his palace. With the Orbs' energies cancelling out, Kahless beamed back to the Quv vo'Kahless and ordered a retreat. In Kahless' absence, control of the Klingon Empire returned to Chancellor Martok while Lore managed to take control of the Red Path and managed to claim the Orb of Destruction. (ST - Day of Blood comics: "Part 3", "Part 4", "Part 5")

After abducting Data, Lore and his brother devised a way to make their positronic brain infinitely scalable, seeking to channel that through the Orb's power to remake the universe in Lore's image. (ST comic: "Star Trek Annual 2024" & ST comic: "The Final Masterpiece")

Finding classified records of Control's plan in 2257, Lore was inspired and manipulated Lily Sato to allow him to lock onto the signal of the Orb of Creation and break into the Pleroma whereupon he unleashed the energies of the Orb of Destruction, unleashing a wave of destruction across the multiverse, reshaping creation into his image. (ST - Pleroma comics: "Part 4", "Part 5")