Progenitor or Progenitors may refer to:
- Individuals:
- Progenitor - a shape-shifting life form believed to have created the Founders
- Shedai Progenitor - a member of the Shedai
- Groups:
- Progenitors - an early race of humanoids which seeded the DNA of numerous planets
- Progenitors (Mariposan) - the first Human inhabitants of Mariposa, whose clones eventually populated the colony
- Other:
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